|Talks|

Programming Protein Networks: Molecular Glues at the Frontier of Drug Discovery

Visiting speaker
Hybrid
Past Talk
Riccardo Sabatini
Chief Data Scientist, Orionis Biosciences
Fri, Jan 24, 2025
3:00 PM UTC
Fri, Jan 24, 2025
3:00 PM UTC
In-person
4 Thomas More St
London E1W 1YW, UK
The Roux Institute
Room
100 Fore Street
Portland, ME 04101
Network Science Institute
2nd floor
Network Science Institute
11th floor
177 Huntington Ave
Boston, MA 02115
Network Science Institute
2nd floor
Room
58 St Katharine's Way
London E1W 1LP, UK

Talk recording

Molecular glues have a transformative potential in drug discovery, allowing targeted manipulation of protein-protein interactions within complex biological networks. These small molecules bypass conventional drug paradigms by reprogramming cellular machinery, offering innovative pathways to address previously undruggable targets.

In the talk Dr. Sabatini will discuss how novel biological assays, robotic automation and advanced numerical models enable the rational discovery and optimization of these compounds, opening new frontiers in therapeutic innovation.

About the speaker
Riccardo Sabatini is a scientist and entrepreneur specializing in numerical modeling of complex systems. His areas of expertise are materials and molecular design, computational genomics and predictive health. Riccardo is co-founder at MIT of the Refugees Action HUB, investment advisor of ENI Next, board member of the Fondazione ENI Enrico Mattei, co-founder of the Quantum ESPRESSO Foundation, founding member of Impact HUB Trieste, angel investor and BoA of leading startups working on numerical models applied to health, energy and financial markets. A speaker at international events and conferences, including TED and WEF, past chairman of the I7 Team at G7 for artificial intelligence, author in top ranking scientific journals and co-author as an inventor of numerous patents and applications. Riccardo was a postdoctoral fellow at the École Polytechnique Fédérale de Lausanne (Switzerland), receiving a Ph.D. in Theory and Numerical Simulation of Condensed Matter from the International School of Advanced Studies (SISSA), MSc.Hon. in Quantum Physics from Trieste University (IT). Previously, he was lead research scientist at Human Longevity and part of the scientific leadership in several projects and companies, including Aiida, Quantum ESPRESSO, FoodCAST, EnerLife, MCA.
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Jan 24, 2025