Biological networks

role of cellular and sub-cellular connections in biological function and disease

This work focuses on building theoretically driven models of genetic, cellular and protein interactions to understand the role of connectivity in function, regulation and disease. By mapping structural relations across pheno and genotypic features of biological systems, we aim to build entirely new paradigms of biological interactions that will dramatically improve disease prevention strategies.

Featured publications

Prevalence of processed foods in major US grocery stores

Babak Ravandi, Gordana Ispirova, Michael Sebek, Peter Mehler, Albert-László Barabási & Giulia Menichetti
Nature Food
January 13, 2025

Higher-order connectomics of human brain function reveals local topological signatures of task decoding, individual identification, and behavior

Andrea Santoro, Federico Battiston, Maxime Lucas, Giovanni Petri, Enrico Amico
Nature Communications
November 26, 2024

Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation

Júlia S. Pinho, Vincent Cunliffe, Kyriacos Kareklas, Giovanni Petri & Rui F. Oliveira
Communications biology
June 13, 2023

Recent publications

Prevalence of processed foods in major US grocery stores

Babak Ravandi, Gordana Ispirova, Michael Sebek, Peter Mehler, Albert-László Barabási & Giulia Menichetti
Nature Food
January 13, 2025

Higher-order connectomics of human brain function reveals local topological signatures of task decoding, individual identification, and behavior

Andrea Santoro, Federico Battiston, Maxime Lucas, Giovanni Petri, Enrico Amico
Nature Communications
November 26, 2024

Representation Learning of Human Disease Mechanisms for a Foundation Model in Rare and Common Diseases

Babak Ravandi, William R. Mowrey, Ayan Chatterjee, Piero Ricchiuto, Parham Haddadi, Mario Abdelmessih, Wei Ding, Simon Lambden, Michaël Ughetto, Ian Barrett, Diethe, Guillermo Del Angel, Tina Eliassi-Rad
bioRxiv
November 21, 2024

Volume-Optimal Persistence Homological Scaffolds of Hemodynamic Networks Covary with MEG Theta-Alpha Aperiodic Dynamics

Nghi Nguyen, Tao Hou, Enrico Amico, Jingyi Zheng, Huajun Huang, Alan D. Kaplan, Giovanni Petri, Joaquín Goñi, Ralph Kaufmann, Yize Zhao, Duy Duong-Tran & Li Shen
Springer Nature Link
October 3, 2024

A Network-Based Framework to Discover Treatment-Response–Predicting Biomarkers for Complex Diseases

Uday S. Shanthamallu, Casey Kilpatrick, Alex Jones, Jonathan Rubin, Alif Saleh, Albert-László Barabási, Viatcheslav R. Akmaev, Susan D. Ghiassian
The Journal of Molecular Diagnostics
October 1, 2024
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Featured project

The Foodome project aims to understand environmental components of coronary heart disease (CHD). The goal is to categorize food ingredients into their chemical constituents in order to identify precise chemical mechanisms that explain how ingested chemicals lead to CHD. The project will take on an immense data collection effort tracking food intake across large populations to capture individualized chemical palettes and determine stability of individuals’ food fingerprint over time. This work will result in the first ever database cataloging an exhaustive list of chemicals that humans consume, which will be used to explore complex relationships between food intake and disease risk.

Associated faculty

Major funders

American Heart Association, NSF, NIH